Tumor Necrosis Factor Alpha and Interleukin 1b Up-Regulate Gastric Mucosal Fas Antigen Expression in Helicobacter pylori Infection
نویسندگان
چکیده
JEANMARIE HOUGHTON,* LISA S. MACERA-BLOCH, LAWRENCE HARRISON, KYUNG H. KIM, AND REJU M. KORAH Division of Gastroenterology and Division of Medical Oncology, Department of Medicine, Department of Microbiology and Molecular Genetics, and Division of Surgical Oncology, Department of Surgery, University of Medicine and Dentistry of New Jersey, Newark, and Division of Gastroenterology, Department of Medicine, Jersey City Medical Center, Jersey City, New Jersey
منابع مشابه
Tumor necrosis factor alpha and interleukin 1beta up-regulate gastric mucosal Fas antigen expression in Helicobacter pylori infection.
Fas-mediated gastric mucosal apoptosis is gaining attention as a cause of tissue damage due to Helicobacter pylori infection. We explored the effects of H. pylori directly, and the effects of the inflammatory environment established subsequent to H. pylori infection, on Fas-mediated apoptosis in a nontransformed gastric mucosal cell line (RGM-1). Exposure to H. pylori-activated peripheral blood...
متن کاملPolaprezinc down-regulates proinflammatory cytokine-induced nuclear factor-kappaB activiation and interleukin-8 expression in gastric epithelial cells.
Gastric epithelial chemokine response is a primary factor in the induction of gastric inflammation associated with Helicobacter pylori infection. Because sustained inflammation is a risk for gastric mucosal damage, agents that down-regulate inflammatory responses may be of therapeutic significance. We examined the effect of polaprezinc, a potent antiulcer agent, on proinflammatory cytokine-indu...
متن کاملCytokine gene polymorphisms influence mucosal cytokine expression, gastric inflammation, and host specific colonisation during Helicobacter pylori infection.
BACKGROUND AND AIMS Recent studies linked cytokine gene polymorphisms to H pylori related gastric cancer development. The current study evaluated the role of cytokine gene polymorphisms for mucosal cytokine expression, the gastric inflammatory response, and bacterial colonisation during H pylori infection. PATIENTS AND METHODS In 207 H pylori infected patients with chronic gastritis, polymorp...
متن کاملAssociation between Helicobacter pylori cagA, babA2 Virulence Factors and Gastric Mucosal Interleukin-33 mRNA Expression and Clinical Outcomes in Dyspeptic Patients
Helicobacter pylori (H. pylori) infection has been reported in more than half of the world human population. It is associated with gastric inflammation and noticeable infiltration of the immune cells to the stomach mucosa by several cytokines secretion. IL-1&beta, IL-18 have been shown to contribute to H. pylori induced gastritis, but the details of inflammation and association of virulence fac...
متن کاملGastric mucosal secretion of interleukin-10: relations to histopathology, Helicobacter pylori status, and tumour necrosis factor-alpha secretion.
BACKGROUND Interleukin-10 (IL-10) is an 18 kDa peptide with a range of anti-inflammatory and immunosuppressive properties. AIM To determine whether this cytokine is involved in gastric mucosal inflammation in Helicobacter pylori infection. METHODS The production of IL-10 by antral mucosal biopsy specimens during short term in vitro culture was determined by measuring IL-10 content of supern...
متن کامل